Elise (Amy Adams) and Michael (Adam Garcia) are the perfect couple who have been dating seemingly forever. Unlike most young couples, they have everything one can wish for - a beautiful house, an upcoming wedding, and a crew of close friends, all coming into Los Angeles for the weekend nuptials. As they each arrive at the house, joyous reunions quickly turn into awkward meetings that bring up both sweet and painful memories. Rich (Aaron Stanford) and Samantha (Melissa Sagemiller) are the best man and maid of honor who are also toying with taking the next step towards the altar. Lana (Mena Suvari) is a neurotic actress with an unstable love life. When all the men she's ever slept with, the forlorn Pockets (Jon Abrahams), children's show host Donovan (Ethan Embry), and drunken actor Simon (James Van Der Beek), all show up for the wedding, chaos ensues. Rounding out the group are Quentin (Colin Hanks), a fast-talking agent who falls hard for the bride's sister (Marnette Patterson), Jennifer (Lauren German), the bride's former roommate with a secret, Franklin (Roger Avary), the definition of a wacky Hollywood director, and Jonathan (Xander Berkeley), the groom's long lost father battling addiction, attempting to reenter his son's life.